Risk Factors for Congenital Cytomegalovirus Infection Following Primary and Nonprimary Maternal Infection

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Congenital cytomegalovirus infection: predisposing maternal factors.

In a prospective study of cytomegalovirus (CMV) infection in pregnancy 69 congenitally infected infants were identified. The age, race, marital status, social class, and parity of the mothers of congenital CMV infants were compared with those of the screened population of women with non-infected infants. These factors were all individually strongly associated with the prevalence of congenital C...

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To determine factors that influence the occurrence of congenital cytomegalovirus (CMV) infection, the authors surveyed prospectively 8,254 infants born in eastern Iowa between October 1989 and June 1994. The authors conducted a case-control study to identify maternal risk factors, matching each CMV-infected infant with three uninfected infants according to hospital and date of birth. CMV strain...

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Primary versus Nonprimary Cytomegalovirus Infection during Pregnancy, Israel

We examined prospectively the outcome of primary and nonprimary maternal cytomegalovirus (CMV) infection during pregnancy among 88 and 120 women, respectively. The risk for vertical transmission was 1.83x higher for primary infection than for nonprimary infection. Nonetheless, congenital CMV disease was diagnosed in both infection groups at similar rates.

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Diagnosis of Maternal and Congenital Cytomegalovirus Infection

Human cytomegalovirus (CMV) is one of the eight viruses belonging to the Herpesviridae family to infect humans. CMV belongs to the Betaherpesvirinae subfamily of viruses characterized by a restricted host spectrum, in vitro replication in fibroblasts of the natural host species in vivo, a slow replication cycle, the induction of intranuclear and intracytoplasmic inclusions and the ability to in...

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Congenital cytomegalovirus infection following first trimester maternal infection: symptoms at birth and outcome.

BACKGROUND The relationship between gestational age at time of maternal cytomegalovirus (CMV) infection and outcome of fetal infection is not well defined because the timing of maternal infection is usually not known. OBJECTIVE To determine whether congenital cytomegalovirus (CMV) infection following primary maternal infection during the first trimester of pregnancy is more likely to lead to ...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2017

ISSN: 1058-4838,1537-6591

DOI: 10.1093/cid/cix337